From the north via the A5:
At the Frankfurt Nordwestkreuz, take the A66 toward Wiesbaden; Exit No. 16, Höchst.

From the south via the A5:
From the Frankfurter Kreuz, continue to Westkreuz; from there, follow the signs toward Höchst and to the A66; from the A66, take Exit No. 16, Höchst.

From the west via the A66:
Exit No. 16, Höchst

More information can be found in the window at left.